Thymosin Alpha-1

Thymosin Alpha-1 (Ta1) is a 28-amino-acid peptide (MW ~3,108 Da) with an acetylated N-terminal serine, a modification important for biological activity. Ta1 is naturally produced by thymic epithelial cells and was first isolated and characterized by Allan Goldstein at George Washington University in the 1970s from the thymic fraction known as Thymosin Fraction 5. The thymus is the central organ of T-cell development, and it undergoes progressive involution with age, a process studied in relation to immunosenescence.

Lyophilized Ta1 is stored refrigerated at 2-8C and is stable for extended periods. Reconstituted solutions are refrigerated and the peptide is stable at pH 5.0-7.5. Given its 28-residue length, Ta1 is more sensitive to physical aggregation than smaller peptides, so gentle swirling rather than vigorous shaking is recommended during reconstitution.