Epithalon (Epitalon)

Epithalon (also written Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly and a molecular weight of approximately 390.35 Da. It was designed to replicate the biological activity of Epithalamin, a polypeptide extract isolated from the bovine pineal gland by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. Its four-residue structure makes it one of the smallest bioactive peptides studied in longevity research.

Lyophilized Epithalon is stored at -20C and is stable for extended periods. Once reconstituted with bacteriostatic water, the solution is refrigerated at 2-8C. The peptide is stable in solution at physiological pH (7.2-7.6) but degrades in strongly acidic conditions, and reconstitution is straightforward given its high aqueous solubility.