Selank Nasal Spray
Top SellerNasal

Sleep & Stress

A heptapeptide nasal spray studied in research on stress and anxiety

01

Intranasal delivery studied via the olfactory and trigeminal pathways

02

Research has examined sedation and dependence measures in studied doses

03

Investigated for allosteric GABA-A modulation, distinct from benzodiazepines

Sleep & Stress

Selank Nasal Spray

Selank nasal spray delivers the heptapeptide selank intranasally, studied in research for its role in stress and anxiety signaling.

50mg bottle · 2.5mg/mL · 20mL99.1% purity

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Quick answer

Selank nasal spray delivers the heptapeptide selank intranasally, studied in research for its role in stress and anxiety signaling.

Format

Nasal

Best use

Sleep & Stress

Evidence

Research-framed

503A Pharmacy
USP <797> Sterile
Provider-Reviewed
Lab-Tested
Cold-Chain
HIPAA

Deep research

About Selank Nasal Spray

Selank Nasal Spray is a pre-mixed, ready-to-use intranasal formulation of the synthetic heptapeptide selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro, MW 751.88 Da) delivered via a calibrated metered-dose pump. Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and is based on the naturally occurring immunomodulatory peptide tuftsin, with a C-terminal Pro-Gly-Pro extension that enhances metabolic stability and CNS penetration.

The nasal spray format requires no reconstitution and is stable at room temperature for up to 30 days after opening. For long-term storage, sealed vials are kept at 2-8C. The peptide solution is stable at pH 5-6.5.

Key benefits

What researchers have looked at

1

Intranasal delivery studied via the olfactory and trigeminal pathways

2

Research has examined sedation and dependence measures in studied doses

3

Investigated for allosteric GABA-A modulation, distinct from benzodiazepines

4

Studied for measures of anxiety in clinical research

5

Research describes effects on BDNF mRNA expression in the hippocampus

6

Examined for enkephalinase inhibition and endogenous enkephalin tone

7

Pre-mixed, ready-to-use format with a calibrated metered pump

8

Derived from the naturally occurring peptide tuftsin

Mechanism

How Selank Nasal Spray is positioned in research

Research describes intranasal selank reaching the brain via the olfactory and trigeminal pathways, bypassing the blood-brain barrier. Electrophysiology studies describe allosteric positive modulation of GABA-A receptors (increased inhibitory postsynaptic current frequency and amplitude without direct agonism), a mechanism distinct from benzodiazepines. The literature also describes effects on BDNF mRNA expression, enkephalinase inhibition, and serotonin metabolite ratios. CNS delivery is reported within 5-10 minutes; plasma half-life is short while CNS duration is several hours.

Published research

What the research has explored

Selank has been studied in clinical research in Russia, where it is an approved anxiolytic nasal spray, with work published in Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova and related journals. Studies have examined anxiety measures, sedation, cognitive measures, and tolerance over follow-up. Post-marketing surveillance reports the most common effect as mild nasal discomfort.

For research and educational purposes only. References to studies describe published literature and do not constitute medical claims, efficacy guarantees, or treatment recommendations.

Questions people ask

Frequently asked questions

What is Selank?+

Selank is a synthetic heptapeptide (MW 751.88 Da) derived from tuftsin, studied in research on stress and anxiety. The nasal spray delivers it intranasally.

How is it different from benzodiazepines?+

Research describes selank as an allosteric GABA-A modulator that preserves natural inhibitory patterns, distinct from the direct potentiation of benzodiazepines.

Does the spray need reconstitution?+

No. It is a pre-mixed, ready-to-use nasal spray with a calibrated metered pump, stable at room temperature for up to 30 days after opening.

Concentration

2.5mg/mL · 20mL

Purity

99.1%

Format

Nasal

Vial

50mg bottle

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